An experiment was carried out to determine the effect of catfish by-product protein hydrolysate (TP), probiotic (LacProbi) and organic acids (Poulacid) in diets on performances and meat quality of Noi chickens. 168 Noi male chickens at 4 weeks of age were randomly distributed in a completely randomized design experiment, with 4 treatments and 3 replicates (each replicate consisted of 14 birds/pen). Treatments were BC: Basal feed + marine fish meal (control); BTP: Basal feed + TP; BTPM: Basal feed + TP + 0.3% probiotic (LacProbi); BTPA: Basal feed + TP + 0.3% organic acid (Poulacid). The results showed that, average daily feed intake (TAAV) was non significant difference between 4 treatments. Howerver, average daily gain (TT) from birds fed BTPM (16.5g/day) and BTPA (16.3 g/day) were slighly higher than that from BTP (15.6g/day) and BC diet (15.7 g/day). Therefore, feed conversion ratio (FCR) in BTPM chickens (3.67 kg feed/kg gain) were sligh lower than the other treatments especially BC (3.93 kg feed/kg gain).The chemical composition (DM, CP, EE and Ash) of chicken meat were non significant diferent among diets, but  EE content were higher in hydrolysate catfish by-product supplementation diets (5.49 - 5.44 %) than that in BC (5.32 %). Moreover, E.coli content in the chicken feces were highest in the chickens fed BC diet (14.1 x 10⁵CFU/g and 190 x 10⁵CFU/g) and lowest in the BTPM chickens (9.1 x 10⁵CFU/g and 153 x 10⁵CFU/g) at 8 and 12 weeks of age. In conclusion,  supplementation of organic acids or probiotic in catfish by-product protein hydrolysate diets of Noi chickens was improved FCR and enhanced fat content  in thick meeat.