An experiment (Exp) was conducted to evaluate the effects of replacing marine fish meal (FM) with Catfish (Pangasius hypophthalmus) by-product protein hydrolysate (CPH) on the performance and health status of weaned piglets. A total of 60 crossbred castrated (Yorkshire x Landrace) male piglets (7.3 ± 1.9 kg/piglet) at weaning were allocated  into five treatment groups in a randomized complete block design. In each group, the piglets were divided randomly into 4 pens (replicates) with 3 piglets per pen.The control diet contained FM as the sole protein supplement (CPH0), and the experimental diets consisted of four different diets in which crude protein (CP) from FM in the CPH0 was replaced by the CP from CPH at different levels: 100% (CPH100), 75% (CPH75), 50% (CPH50) and 25% (CPH25). The results showed that, average daily feed intake (ADFI)  did not differ significantly among treatments (P>0.05). Howerver, the highest and the lowest average daily gain (ADG) were recorded for piglets on CPH100 (362.1 g/day) and CPH0 (336.0 g/day) (P

Key words: Catfish by–product, Protein hydrolysate, diarrhoea incidence, faecal score, weaned piglets