Promoting the development of industrial economies sustainably in the areas where ethnic minorities are living is one of key goals in Vietnam as this supports to create a balanced development amongst ethnic groups as well as regions. During industrialization era, combining sustainable industrial engagement with the development of ethnic minority can be considered as indispensable need. This study has analyzed some main obstacles in the sustainable development of industry in the localities where ethnic minority people have been living in Can Tho city and Kien Giang province and proposed some solutions. Based on the mixed method, the research data was collected through studying documents, conducting survey, carrying out interview and taking field trip. The research results have shown three major issues that were concluded from data analysis. Firstly, although it is much potential, the industrial activities in some areas where ethnic minorities have been living in selected localities are still underdeveloped. Secondly, some obstacles including low in literacy rate and labor qualification, lack of capital and technology investment, limitation of infrastructure, lack of market information and government policy; and the dispersion of industries were analyzed in order to judge how challenging in developing industrial economies in the localities. Finally, a number of solutions have been proposed to support the development of industry in the local areas consisting of training some appropriate professions to the local situation, giving loan with low interest rates, advising on local industrial development, upgrading transportations system and disseminating and enforcing government policies.