The paper is aimed at identifying the factors influencing the responsiveness of textbooks and course readings at an academic library in the Mekong Delta, Vietnam. Using a quantitative approach, online survey was undertaken with 444 participants (370 undergraduates, 66 Master students and 8 PhD candidates). The findings from the study show that five groups of factors influenced the responsiveness of textbooks and course readings. They include textbook features, the publisher and author, the learner, library policy, and the teacher. Technology and Library staff had no influence on the responsiveness of textbooks and course readings. The learner was identified as the group with the strongest and positive influence whereas library policy was found to be the weakest and least positive influence on the responsiveness. The paper concludes by making recommendations to improve the responsiveness of textbooks and course readings for academic libraries.