English is essential to students in the Vietnamese context, and using English in real-world communication situations is even more demanding for them. Therefore, many studies have been conducted to research issues related to students’ using English in their communication. This study contributes to the literature of this field. Mainly, this study was conducted quantitatively to measure the factors affecting English-major students’ willingness to communicate (WTC) in the case of Vietnam. A 30-item questionnaire was used to collect data. The study revealed that students’ WTC was significantly affected by their nervousness, pressure on social comparison, tension, speaking partners, classroom atmosphere, and lecturers’ characteristics. Based on the findings, this current study encourages English instructors to improve their teaching performances by participating in professional development training and cultivating noble qualities of teaching profession to help gain their students’ trust and respect. As a result, students’ WTC is expected to be higher while working with high-quality teachers with sufficient professional knowledge and ethics.