The development of technology applications has brought many benefits to users. However, users face certain risks when adopting new technology applications. This leads to barriers affecting the acceptance of new technology applications. The study was carried out to identify the barriers affecting the acceptance of tourism apps by tourists. Research data were collected by the method of quota sampling, with a sample size of 222 tourists who have visited and experienced tourism services at famous destinations in Vietnam. Qualitative research methods and quantitative research methods are both applied to test the research hypotheses. The structural equation modeling (SEM) has demonstrated that insecurity and discomfort positively affect tourists’ perceived risk of tourism apps. Also, insecurity, discomfort, and perceived risk negatively affect tourists’ acceptance of travel apps.