Two highly productive emergent macrophytes, Monochoria hastata and Colocasia esculenta were grown in experimental subsurface flow, sand-based wetlands at the dormitory of Cantho University. The hydraulic loading rate was tested sequentially 80 mmday^-1 and 160mmday^-1 in two months. The results showed that the effluent of domestic wastewater was anaerobic condition and contains plenty of pollutants which can be estimated by a low dissolved oxygen concentration of 0.69 mgL^-1, 182.36 mgL^-1 COD, 21.74 mgL^-1TN and 5.29 mgL^-1 TP. Under the low hydraulic loading rate, the constructed wetland planted Monochoria hastata had the removal efficiency of 85.14% COD, 39.32 % TN and 72.19 % TP while Colocasia esculenta removed COD; TN; TP 88.66%; 54.01 %; 92.80% respectively. Under high hydraulic loading rate, the constructed wetland planted Monochoria hastata achieved the removal efficiency of 87.05% COD, 48.21% TN and 76.17% TP whereas the constructed wetland planted Colocasia esculenta removed 92.25% COD, 67.77% TN and 93.95% TP. Based on the experimental results obtained to date, the constructed wetland system would be a promising system for domestic wastewater treatment.