The factor of students' learning attitudes undoubtedly affects their learning outcomes. This study investigates factors influencing Vietnamese students’ attitudes toward English learning in a tertiary institution in the Mekong region to help local educators enhance the quality of teaching and learning English in this region, considered a “low-land” in the education of Vietnam. This study was conducted qualitatively, using structured interviews to collect data from 69 first-year students. The study revealed that internal and external factors affected the students’ attitudes. Regarding the internal factors, students’ self-confidence, risk-taking willingness, anxiety, curiosity, and awareness of the importance of English in their future considerably impacted their attitudes towards English learning. On the other hand, the study found some external factors, including teaching and learning materials, content, curriculum design, and teacher-related factors, including teacher personalities, professional knowledge, teacher communication, and teacher attitudes. Some discussions, pedagogical implications, and recommendations were displayed at the end of the current paper.