One of the main goals of language learners is to master all four skills of listening, speaking, reading and writing when it comes to their acquisition of the target language. However, during the process of learning English, learners inevitably face a variety of challenges related to their writing including grammatical errors, word choice, organization, idea development, and most importantly their difficulties in using collocations (Duong & Nguyen, 2021). Therefore, this study has been conducted to investigate the students’ use of English collocations in their academic essays associated with their difficulties so that appropriate pedagogical approaches and practices would be taken into consideration in order to help students improve their English collocational competences in academic writing. This descriptive study was carried out with 103 English-majored students of the High-quality program of the School of Foreign Languages ​​at Can Tho University, Vietnam. A 5-point Likert scale survey with 18 questionnaire items was employed to examine the frequency of students' exposure to as well as their usage of English collocations, and their difficulties in using English collocations. The results of this study have shown that the most commonly used collocations in the students’ academic essays were ‘verb + noun’, and ‘adjective + noun’ lexical collocations. Additionally, the research outcomes have revealed that the types of English collocations that the students were more likely to make the most mistakes belonged to ‘verb + adverb’, and ‘adjective + noun’ lexical collocations.