The study aims to identify factors affecting the creativity of university lecturers in Vietnam. Research data were collected from 310 lecturers working at universities using the quota sampling method. Structural Equation Modeling (SEM) was applied. Five factors impact the creativity of lecturers: Organizational support, Work motivation, Intrinsic motivation, Occupational stress, and Job autonomy. In particular, occupational stress negatively affected the creativity of lecturers. Besides, this study proposes several administrative implications to promote the creativity of Vietnamese university lecturers.