Molasses was a by-product of the sugar processing industry which could be supplemented for rabbits. In the Mekong Delta of Vietnam, rabbit producers fed locally available feedstuffs including natural grasses, wild vegetables, and agro-industrial by-products. This study aimed to evaluate the effects of maize and molasses supplementation, at different levels, in diets on the reproductive performance of does through two litters. The experiment included 30 New Zealand White crossbred doe rabbits, aged between 6-6.5 months and with an average weight of 2680 ± 58.69 g/per. The rabbits were arranged in a factorial design with two factors and five replications, with one doe rabbit per experimental unit. The first factor was the energy source supply in the diet (maize and molasses), and the second factor was the levels of digestible energy (DE) in the diet (10.5; 11.0; and 11.5 MJ/kgDM). The results showed that DM,OM, CP, EE, DE intake were improved at the level of DE11.5 and CP intake had an interaction between energy sources and DE levels in both two litters. Postpartum weight gain increased following increasing DE levels in the first litter, however, it was improved in the molasses group in the second litter. Milk yield was increased following increasing DE levels in the second litter. There was an interaction between energy sources and DE levels in terms of litter size at birth and litter size at weaning in the second litter. In conclusion, disgestible energy at level of 11.5 MJ/kgDM improved in terms of nutrient intake and milk yield.