A study on the major fisheries was conducted from August 2017 to April 2018 in coastal provinces of the Mekong Delta, Vietnam. Results showed that the gillnets, trawl nets, and stow nets were the main fishing gears, accounted for the highest number of fishing boats and yields. All the fishing gears exploited for the whole year-round. The results also indicated that gillnets fishery is the largest scale (10.99 tons). The most effective fishing activity of gillnets fishy was the highest profit (298 million VND per year) (p