Ninh Kieu District is located in the center of Can Tho City, established under the Government's Decree No. 05/2004/ND-CP. This is a modern and rich district, with a history of formation and development associated with the Mekong Delta. According to statistics in 2019, Ninh Kieu District has an average population of 280,792 people, with a population density of 9,605 people/km2 and an area of 29.23 km2. In the current period, the urbanization process in Ninh Kieu District takes place at a fast and strong pace. This has made it impossible for the urban drainage system to keep up with this change, thereby creating great difficulties for the drainage management here. In order to deal with these enormous challenges, the managers in this area need to incorporate new technologies into drainage management. This paper presents the main result of building a spatial database to support drainage management for Ninh Kieu District. This is considered as a fundamental source of data for application of GIS in urban drainage research and management in Ninh Kieu District.