Shallot is the major crop of Vĩnh Châu town, Sóc Trăng province. Pests have currently caused severe damages on shallot yield under both field and storage conditions. Bulb rot is one of the most serious problems. Five pathogens have been identified, i.e., Fusarium oxysporum (basal rot), Aspergillus niger (black mold), Collectotrichum gloeosporioides (anthracnose), Erwinia carotovora (soft rot) and Pseudomonas aeruginosa (bulb rot). Chemicals have been used as the major means but lead to adverse impacts on human health and the ecosystem. This paper presents the research results on biological control of shallot bulb rot, focusing on Pseudomonas aeruginosa, using antagonistic microorganisms and plant extracts of the Plant Pathology Research Group at the Biotechnology R&D Institute of Can Tho University since 2015.