MIS-CTU's creativity, fabrication and start-up activities were facing many challenges: (1) the number of participants has decreased significantly after the Covid-19 pandemic; (2) Most of the staffs of MIS-CTU were engineering students; (3) Limited student entrepreneurship activities. Therefore, Mr. Nguyen had to change the operating model of MIS-CTU so that the above difficulties can be solved before the beginning of 2022.