The paper presents a student-led model for developing creative thinking to create high-quality human resources in the industrial revolution. This model is developed based on an open space with full of modern equipment for learning and
scientific research activities of Can Tho University students. This open space is called the Maker Innovation Space and is run by most students. Students participating in projects such as Undergraduate Research Initiative (URI), engineering project in community services (EPICS), or Maker to Entrepreneur Program (MEP), scientific research projects, course projects or graduation theses can freely use this space. In addition, the Maker Innovation Space also organizes many STEM/STEAM training courses for both students and high school teachers to deploy scientific research programs to high schools. The Maker Innovation Space of Can Tho University works very effectively and is considered as a creative thinking model to create high-quality human resources for the economic and social development of the Mekong Delta
region.