Abstract—The study aimed to assess the evolution of ambient air quality in An Giang province during 2010-2020. Air samples collected in urban areas, traffic, tourism, industrial clusters, brick kilns, quarries, landfills, and background areas were analyzed for temperature (T), noise, total suspended particulates (TSP), carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxides (SO2), ozone (O3), ammonia (NH3), hydrogen sulfide (H2S), and hydrogen fluoride (HF). The findings were compared with the Vietnamese standard on air quality. Pearson correlation and principal component analysis (PCA) were performed to recognize the correlation between pollutants and potential pollution sources. The results showed that the average values of air quality parameters in An Giang province during the study period temporally fluctuated but within the allowable limits. Moreover, the air quality parameters were well correlated, especially temperature and ozone. Three PCs obtained from PCA could explain 87.50% of the air quality variations with a significant contribution of all parameters. It is found that CO, NO2 and SO2 originated mainly from traffic and urban areas. While NH3 and H2S were dominant in the landfill areas, HF was from brick kilns. Consequently, the traffic and urban areas are considered the most influential contributors to air pollution in the study area.