This study evaluates the quality of wastewater effluent collected from domestic wastewater, industrial wastewater, medical wastewater, and aquaculture wastewater in Tien Giang province, Vietnam. The quality of domestic wastewater effluent is assessed using Vietnamese standard QCVN 14:2008/BTNMT while the effluent quality of industrial, medical and aquaculture wastewater is assessed using QCVN 40:2011/BTNMT. The effluent quality indicators of pH, temp, BOD, COD, TSS, N-NH₄⁺, N-NO₃^-, P-PO₄^3-, TN, TP, S^2-, CN^-, As, Hg, Ni, Pb, Phenol, Oil & grease, Coliform, Shigella, Salmonella, Vibriocholerae were used in the assessment. The results showed that TSS, N-NH₄⁺, TP, Coliform in industrial wastewater effluent; N-NH₄⁺ in medical wastewater effluent; TSS and coliform in aquaculture wastewater effluent; TSS, N-NH₄⁺ and coliform in domestic wastewater effluent at some locations exceeded the allowable limits. The effluent quality of industrial, medical, aquaculture and domestic wastewater was seasonally fluctuated. COD, BOD, TSS in industrial wastewater in the rainy season were higher than those in the dry season, while BOD and COD in medical wastewater, livestock wastewater and domestic wastewater in the dry season were higher than those in the rainy season. In all types of wastewater effluent, the concentration of nutrients in the rainy season were lower than those in the dry season. The effluent quality indicators of heavy metals, sulfide, cyanide and groups of pathogenic microorganisms were not detected in wastewater effluents. Oil and grease were detected only at the AW2 site during the dry season. The results showed that there is a need for technological solutions to improve the thorough treatment of TSS, N-NH₄⁺, TP, coliform in wastewater to reduce risks to the natural environment and human health