This study was conducted to investigate the generation, composition and management of domestic solid waste in Nhon Nghia commune, Phong Dien district, Can Tho city in Vietnam. Households, garbage collectors and environmental managers were interviewed for the required information. The results showed that the rate of domestic solid waste generation is 0.65 kg/person/day with the total amount of domestic waste generated 3,998 tons/year. In which, 74.32% of waste is biodegradable and recyclable. The separation of waste at source in the study area is relatively good, accounting for 67%, most of the waste is classified into waste that can be reused and recycled, accounting for 45%. Waste collection and transportation system in Nhon Nghia commune has not been completed since among the four studied hamlets, only two hamlets, Nhon Hung A and Nhon Khanh A, have solid waste collection services. The results presented that the majority of households self-treat their waste by burning, burying (23%) and discharging directly into the environment (27%). The remaining amount of domestic solid waste is treated at the landfill. People's awareness about the negative impacts that solid waste brings to the environment and health is relatively high. It is forecasted that by 2025, the amount of domestic solid waste will increase along with the population growth rate, increasing from 3,998 tons/year (in 2022) to 4,164 tons/year (in 2025). Strengthening segregation at source, improving the collection and transportation system, raising public awareness and strictly handling violations of discharge should be done to improve the efficiency of domestic solid waste management.