Bisphenol A (BPA), that is one of a common industrial chemicals, has been linked to differences in
mental health problem of children (e.g. autism), and suggested to be a risk factor to the nervous system
causing for Parkinson and Alzheimer in the children. To demonstrate the impact of BPA on the
neurodevelopmental processes relating to human behaviors, behavioral modifications in the flies
Drosophila melanogaster exposed to BPA is reported in this study. In the life cycle assay, we tested the
effects of five concentrations of BPA (0.5 mM, 1 mM, 2 mM, 4 mM and 40 mM) and found a statistically
significant decrease in a number of pupae and adult flies for the high dose treated groups. The F1
generation of flies exposed to BPA 1 mM was used for the assays of Odor–Taste practice, social
interaction and locomotion ability. The results showed that memorial skill and locomotion ability were
declined in the Drosophila treated by BPA 1 mM in comparison with the control group. In addition, we
also observed the abnormal social interaction of the BPA-exposed flies in a social environment. These
results demonstrated that BPA agent causes a risk and tremendous impact on the mental health
behavior of Drosophila. This study can suggest the practicability of using Drosophila as an animal
model in the upcoming studies of neurobehavioral developmental disorders, and of screening agents for
treating human nervous system-relating diseases