This study aimed to evaluate the effects of replacing water spinach (Ipomoea aquatica) (WS) for commercial pellet feed in the diets on growth performance, nutrient digestibility, carcass characteristics, and meat quality of growing crossbred rabbits. The experiment was a completely randomized design with 6 treatments, 5 replications, and 2 rabbits at 35 days old (365±11.9 g/per) with balanced sexes per trial unit. The six treatments consisted of different levels of replacing commercial pellet feed with water spinach, namely 0%, 20%, 40%, 60%, 80%, and 100% dry matter (%DM) in the diets, corresponding to WS0, WS20, WS40, WS60, WS80, and WS100, respectively. The experiment was conducted for 12 weeks. The experimental nutrient digestible period was conducted during the 6th week of the experiment and carried out for 6 days continuously. After completing the feeding trial, all rabbits were slaughtered to evaluate the carcass characteristics and meat quality. The results indicated that increasing levels of WS in the diet decreased (p