Vietnam’s Mekong Delta region contains a sizable amount of acid-sulfate soil, which has properties that harm plants, such as low pH, aluminum and iron toxicity, hydrogen sulfide and sulfate acid. The study aims to gather helpful information about the problems with acid sulfate soils’ chemical makeup so that suggestions can be made for improving these soils in the Mekong Delta. These methods mainly review studies and projects on the properties, constraints and management improvement of acid-sulfate soils and recommend the proper methods for sustainable use. The Mekong Delta contains many sulfidic or acid-sulfate-producing materials. Soils that contain acid sulfate are especially vulnerable to the consequences of climate change. Therefore, evaluating and predicting how acidic soil impacts soil quality and the affected factors such as drought, water scarcity, rainstorms, floods and saltwater intrusion are essential. Selecting cultivars that can withstand acid sulfate or salt is easy and inexpensive. Designing appropriate farming models is necessary in the interim. To correctly manage and exploit acid sulfate soils in the current situation, one must also be aware of their distribution, physicochemical makeup and biological properties.