The aim of this paper is to apply the framework for youth entrepreneurship development in Tra Vinh province, Vietnam. This paper explores entrepreneurship from the perspective of youth intention for start-up business. Our findings show that youth entrepreneurship in Vietnam has gained more attention by the government in recent years, and youth entrepreneurship is considered as a way of enhancing economic development. The research results showed the entrepreneurial passion, business willingness, business experiences, business mental, business institution environment, entrepreneurial motivations, entrepreneurial education, entrepreneurial behavior, Entrepreneurial barriers are affected to the youth entrepreneurship intention in Tra Vinh province, Vietnam.