The study was conducted from making surveys of 120 employees working in the hotel sector in Kien Giang Province for indicating determinants that influence their job performance such as Job Motivation, Working Environment, Leadership, and Personal Competency. The research methodologies of Cronbach Alpha, Exploratory Factor Analysis (EFA) and Multivariate regression were employed to identify these influential factors. The major findings indicated that these four groups of factors showing a positive correlation to the employee’s job performance; in which, Leadership factors are the most influential elements that cause better working results among staff. Finally, four groups of recommendations and strategic implications to improve such performance are proposed. Keywords: hotel sector, Employee’s Job Performance, Job Motivation, Kien Giang Province.