This paper reports a mixed-methods study designed to explore teachers’ perceptions about using PowerPoint (PPT) as an ICT (Information and Communications Technology) tool in vocabulary teaching in Kien Giang province, Vietnam. The data were collected from the questionnaire and interviews. Participants were sixty EFL teachers from five colleges in Kien Giang province. The findings reveal that participating teachers perceived PowerPoint use in vocabulary instruction as a useful instructional tool; however, there was no significant differences in their perceptions. These participants reported obstacles such as time investment, insufficient knowledge in information technology (IT), and lack of IT facilities. Pedagogical implications are made to encourage the potential use of PPT in vocabulary instruction.