The objective of this study is to assess water storage potential in Dong Thap Muoi, Dong Thap province under the climate change perspective. To achieve the above objective, the potential water storage area was firstly determined from the topographic map and the maximum water level corresponding to certain frequency at the end of the flood season; the correlation of maximum water level among the stations was determined, thereby to estimate water storage potential under the scenarios of climate change in the periods of 2030, 2040 and 2050; water demand of different water-using sectors was estimated and thus, the capacity to replenish water from the storage was assessed for the next year dry season months. The results show that the area of Tram Chim as well as the surrounding area has the potential to store water at the end of the flood season, thanks to low topography and wetland ecological conservation area. Results of estimating water demand for the downstream area show that the majority of water demand is for agriculture (cultivation). Under climate change conditions, the water storage potential of Tram Chim and the surrounding areas can be added to existing water sources to partially meet water needs (mainly to ensure 100% supply for domestic water and industry sector). In particular, by 2030, this storage waterwill supply for four months water demand in the dry season of 19.53%, 19.54% and 19.54% corresponding to scenarios RCP2.6, RCP4.5 and RCP8.5, respectively (in the frequency of 3%).The results are the basis for the initial step to provide more scientific basis to help people, policy makers and authorities have a comprehensive view and make appropriate decisions for the whole region in the context of climate change.