In this study, Belinostat (Beleodaq or PDX101) was successfully synthesized through 6 steps: i) Preparation of m-Nitrobenzaldehyde using KNO3/H2SO4. ii) Use of Wittig reaction with ylide as the nucleophile. iii) Reduction of –NO2 group. iv) Preparation of sulfonyl chloride group. v) Addition reaction with aniline as the nucleophile. vi) Synthesis of hydroxamate by reaction with NH2OH.HCl. Belinostat was obtained in the yield about 25%. The structure of intermediates and final product were confirmed by IR, 1H-NMR spectra.