This study was conducted by interviewing 152 households culturing snake head fish by 3 farming system located in An Giang, Tra Vinh, Vinh Long and Hau Giang from February to December, 2014. The results showed that the total of snake head cultured area in Tra Vinh is larger than that of the other provinces. Happa farming system in river has the FCR of 3.5±1.5 that is higher than that in pond and happa in pond. Survival rate in 3 farming systems including pond, happa in pond and happa in river are 57.5±18.8%; 59.0±31.1% and 63.3±18.2% respectively. Pond cultured system has the yield of 189.7±104.5 ton/ha/crop, while happa in pond has 3.4±2.4 ton/ha/crop and happa in river has 5.1±2.8 ton/ha/crop. Total investment cost are 4,802.1±3,449.1 for pond, 75.8±68.1 for happa in pond and 131.3±74.8 for happa in river with the producing cost of (24.8±8.7) 1,000 VND/kg; (21.9±8.3) 1,000 VND/kg and (26.4±6.2) 1,000 VND/kg respectively. the selling price are (26.7±3.1) 1,000 VND for pond; (30.4±2.4) 1,000VND for happa in pond and (31.6±3.1) 1,000 VND for happa in river with profits are (813.8±1,714.9); (27.9±33.2) and (32,30±40,46) VND million/ha/crop respectively. Factors affect the farming systems include storm, water temperature, drought and salinity.