An experiment was carried out at household in Tra Vinh province to evaluate the effects of replacing of dietary fish meal by catfish (Pangasius hypophthalmus) by-products on growth performance of growing Crossbred Muscovy ducks. A total of 150 Crossbred Muscovy ducks at four weeks of age were arranged in a completely randomized design with 5 treatments and 3 replicates with 10 birds (balanced for sex) per experimental unit. The treatments were a control diet with only fish meal protein (CF0) and in the others fish meal protein was replaced by catfish by-products at different levels of 25% (CF25), 50% (CF50), 75% (CF75) and 100% (CF100) of the amount of the fish meal protein of the CF0 diet.