This study applies the contingent valuation method (CVM) to estimate urban residents’ willingness to pay for an ecosystem conservation program in U Minh national forest, one of the most important protected areas in the Mekong Delta. The results showed that most households are willing to make a monthly contribution of about VND 85,515 (US$ 3.72) toward the program. Overall, the urban residents of the Mekong Delta have agreed to contribute about US$ 55 million annually to the U Minh forest ecosystem conservation project. This annual aggregate contribution is relatively large enough to elicit interest from the government, policymakers, and other stakeholders to financially invest in preserving the forest ecosystem.