This chapter used a small survey of 80 rice farmers who applied pesticides in the Vietnamese Mekong Delta to analyze their perceptions and demand for pesticide use. The results performed the majority of farmers did not wear protective clothing suggested by WHO for pesticide safety use although they could recognize the harmful effects of pesticides. Most of farmers declared that they asked for information or instructions related to pesticide use and pest prevention from retailers (72.5 percent) and over half of them (52.5 percent) sold their pesticide empty packages. The study also showed that an increase in output price or farmers who thought an increasing tendency of insects and diseases had positive impacts on pesticides, while farmers who had knowledge on natural enemies or took part in short trainings or workshops applied less pesticides than others.