This study aims to identify determinants of the bank profitability of the commercial banks in Vietnam between 2010 and 2018. The empirical results show that concentration ratio variable was negatively related to capital-based returns and before- tax returns; government ownership variable also effect on before-tax returns and staff expense on assets, as well as before-tax returns, staff expense, and provision for loan losses on assets negatively, whereas capital ratio variable is positively related to assets- based returns. In addition, no support is found for both the expense preference theory and the Edwards – Heggestad – Mingo risk aversion effect.