The objective of the study is to demonstrate the relationship between the local people’s pro-environmental awareness and behavior in developing community-based tourism in the Mekong Delta. The data were collected from 210 local people involved in developing community-based tourism in Can Tho City, An Giang Province, Dong Thap Province, and Tien Giang Province. The structural equation modeling (SEM)was applied.The study has proved that environmental education and environmental management positively influence pro-environmental awareness of local people. Also, the study has shown a positive relationship between the pro-environmental awareness and behavior of local people towards the development of community-based tourism in the Mekong Delta.