Red Claw Crab (Sesarma sederi) is an economically important species in Vietnam. This study aimed to investigate the suitable salinity for the best growth and survival of this species. The study comprised of six treatments of salinities (i) 10‰, (ii) 15‰, (iii) 20‰, (iv) 25‰, (v) 30‰, and (vi) 35‰, with three replicates each. The experiment was conducted in 120-L plastic tanks, at stocking density of 100 larvae/liter. Artemia were the main live food for larval culture. Results showed that Red Claw Crab larvae performed through four stages of Zoea, one stage of Megalopa to become Crablets. After 17 days of larval rearing, crablets appeared at most treatments. Crablets at treatments 20‰ performed the best with highest survival rate (16.9 ± 1.68 %) and the largest carapace width (1.29 ± 0.04 cm) and were significantly different (P