The main purpose of this research was to investigate the accelerated shelf-life of phenolic compounds in Polygonum multiflorum (Thunb.) root extract and its spray dried products at various temperatures. Using the Q10 model helped in observing the degradation of the total polyphenol content (TPC) and antioxidant capacity (AC) of the product, while enabling an accurate prediction of the its shelf-life at different storage temperatures. The results showed that the degradation of TPC and AC of the extract was rapid at elevated temperatures. The spray-dried products maintained TPC and AC better than the extract. TPC and AC retention of 85% of the extract were approximately 42.4 and 5.1 days at 30°C, respectively. While TPC and AC retention of 85% of gum arabic were 6.2 and 13.1 days, TPC and AC retention of 85% of maltodextrin (DE 16-19) were 14.68 and 7.16 days, respectively. The obtained model was reliable and easy to use.