Dendronereis chipolini is an important brackish water polychaete and has been wildly used as fattening feed for marine shrimp broodstocks. Investigation into the effects of salinity on performance of this worm species is fundamental for the development of mass culture procedure to produce feed for fattening shrimp broodstock and reduce pressure on wild catch. The study was conducted in a tank system with an area of 0.25 m² in which the young worms (0.9±0.2 cm in length and 0.007±0.003 g in body weight) were stocked at 100 inds/tank. Four salinity treatments, including 15, 20, 25, 30 ppt, were designed with three replicates each. The worms were fed once a day at 9 am with commercial shrimp feed at a rate of 3% body weight. After 150 days of rearing, the fastest growth of worms was recorded in 20 ppt. The survival rate was also higher in 20 ppt but no significant difference was found (p>0.05) between treatments. Higher absolute fecundity (103,890±17,389 and 112,740±22,328 eggs/female) was recorded at 20 and 25 ppt, respectively. The males in 20 ppt also produced a higher number of sperms. Overall, the polychaete D. chipolini reared at 20 ppt performed higher growth, survival and reproduction rates.