This paper researched influenced factors of sustainable tourism development on sensitive ecological area at Mo O beach, Soc Trang province, Vietnam by quantitative methods. Questionnaires were conducted with a total of 121 residents who are local people living in Trung Binh commune, Tran De district, Soc Trang province. Through Exploratory Factor Analysis, and Linear Regression Analysis results, the findings reveal that there are four factors affecting sustainably tourism development in Mo O sensitive ecological area namely biodiversity (33.7%), facilities – infrastructure (24.2%), administration of government (23.6%), people with environment (18.5%). Besides, this research also proposes some solutions related to biodiversity, administration of the government, material facilities – infrastructure, environment to develop effectively sustainable tourism in sensitive coastal areas.