The purpose of this research is to analyse potentials, current situations and find solutions to boosting tourism development of the waterway in Can Tho City. The result indicated that waterway – based tourism has significantly potential resources to attract tourists by field and accessing the present data. However, river tour products of Can Tho City are monotonous and overlapping compared with those of other provinces in the Mekong Delta. In order to develop waterway – based tourism effectively, the government should propose subtle policies in developing infrastructure, protecting environment, appealing investments and making a differentiation among provinces in Mekong Delta.