This paper was on intercultural communication competence in English language teaching from Can Tho EFL student-teachers (practitioners) in high school practice in Can Tho City. The study investigated senior EFL student teachers’ perceptions and practices of Intercultural Communication Competence (ICC), a case in a School of Foreign Language (SFL) in Can Tho University (CTU), the biggest university in Mekong Delta, Vietnam. Forty-five seniors practicing teaching called student-teachers were invited to participate into the study which used a questionnaire to collect quantitative data. The result showed that EFL student-teachers had fairly good perceptions of Intercultural Communication Competence. In addition, the result also indicated that their willingness to practice ICC in language teaching was recognized actively through their teaching performances.