The paper proposes dissolved oxygen (DO) simulation modeling of catfish pond with cellular automata (CA). Dissolved oxygen parameter of catfish pond is an important indicator of water quality. It was collected by the sensor system at the same time and was used as input data for a simulation model. Simulation model can evaluate the change of DO quality in each location and time of survey in ponds with two scenarios: (1) Simulate of DO quality when the catfish pond is not affected by water flow; (2) Simulate of DO quality when the catfish pond is affected by flow.