Giant freshwater prawn farming is recently developed rapidly in the  Mekong Delta with a total of 15,270 ha and 5,306 tons, especially the coastal provinces cover for 90.1% of total culture area and 64.8% of total production. This study aims to evaluate the growth, yields and financial aspects of  giant freshwater prawn (Macrobrachium rosenbergii) farming at different brackish intrusion areas in order to contribute to further development of the industry.  A total of 9 ponds were selected for prawn culture in Tra Vinh province, including Duyen Hai district (3 ponds), Tra Cu district (3 ponds) and Cau Ngang District (3 ponds). The ponds were 4000 m² each in area and 1.5 m in depth. These ponds were also used for tiger shrimp culture in the dry season. After the tiger shrimp culture crop, the ponds were prepared for freshwater prawn stocking at density of 7 inds/m². Prawn were fed with pellet feed of 33 - 33% protein and at feeding rates of 2 - 15%  body weight. Culture duration was 6 months. Results showed that prawns cultured in Duyen Hai with highest water salinities (average of  6.33±0.04‰) and in Tra Cu (average salinity of  4.14±0.04‰) had fastest growth and reach body weight of  39.5 and 36.1 g, respectively, compared to those in Cau Ngang district where with average water salinity of 3.36±2.15‰, and prawn body weight of 26.5 g.   Prawns cultured in higher water salinities  (Duyen Hai and Tra Cu) have lower spawning rates compared to those in lower salinities (Cau Ngang).  Prawn yields and net income in Duyen Hai ((1,342 kg/ha/crop and 199 millions VND/ha/crop) and in Tra Cu (1,269 kg/ha/crop, 156 million VND/ha/crop) were significantly higher than those in Cau Ngang (988 kg/ha/crop and 74,2 millions VND/ha/crop). The findings indicate important evidence and great potential of giant freshwater prawn farming in the brackish water area of the Mekong Delta.