In this study, five novel quinazolin-4-one structures with a benzimidazole moiety incorporated at the C-2 position through a thioether linkage (10a-e) have been successfully designed and synthesized in good yields. The developed synthetic patway is simple, efficient and suitable for large scale synthesis. The structures of the prepared hybrid heterocycles were fully characterized by FT-IR, HRMS, ¹H-NMR and ¹³C-NMR spectra.