A study was conducted at the experimental farm in Long Hoa commune, Binh Thuy district, Can Tho City to evaluate effects of different replacement levels of Paederia tomentosa to Paspalum atratum in diets on nutrient utilization, growth performance and economic returns of growing crossbred rabbits (Californian x địa phương). The feeding trial was a completely randomized design with 5 treatments and 3 replications. The treatments were 5 levels of 0, 25, 50, 75 and 100% Paederia tomentosa replacing Paspalum atratum(correspondings to the RM0, RM25, RM50, RM75 and RM100 treatments). There were 4 growing crossbred rabbits at 30 days of age (balanced sex) per experimental unit and the experimental time lasted for 12 weeks. The results showed that daily intakes of dry matter, crude protein and metabolizable energy were significantly higher for the RM75 treatment