Vermicelli production generates wastewater that is rich in organic and nutrient pollutants, which poses signi4cant environmental challenges. Conventional biological treatments, either alone or in combination with other methods, often fail to achieve high e6ciency and operational stability. 0is study explored the potential of the Fenton process, followed by aerobic activated sludge treatment, to enhance the biodegradability and mineralization of organic substances in vermicelli wastewater. Orientation experiments were performed to examine the e,ects of operating variables such as pH, reaction time, settling time, and ratio H2O2/Fe2+ on COD removal in order to select the optimal conditions for operating the model in a batch of 20 L, that is, pH � 3, reaction time of 90 min, settling time of 90 min, and ratio of H2O2/Fe2+ used 3 :1 (4.5 :1.5 g/L). 0e removal e6ciencies of COD, BOD5, TN, TP, and SS reached 75.83%, 67.26%, 28.24%, 26.63%, and 91.9%, respectively. 0e BOD5/COD increased from 0.52 to 0.63, facilitating aerobic activated sludge, which had batch conditions of 15 L with pH of 6.5–8.5, DO ≥3 mg/L, additional nutrients with a dose of 12 mg/L, retention time of 14 h, and settling time of 2 h. As a result, the removal rate of those parameters climbed quite notably, except in SS (95.6%, 96.0%, 84.6%, 84.1%, and 83.6%), and their concentration parameters remained within the allowance levels of the National Technical Regulation in Vietnam before being discharged into the environment. However, the e6ciency of treatment in the aerobic activated sludge stage for removing COD and BOD5 was not as high as anticipated (83% and 87.33%, respectively) owing to the inGuence of the high TDS concentration. 0us, additional research is required to address this challenge. 0e integrated treatment system combining the Fenton process with aerobic activated sludge demonstrated signi4cant potential for the e,ective reduction of organic and nutrient pollutants in vermicelli wastewater, thereby achieving compliance with regulatory standards. However, the observed limitations in COD and BOD5 removal e6ciency, likely due to elevated TDS levels, indicate the need for further investigation and optimization to enhance the overall treatment performance.