The objective of the study is to determine the factors that affect the relationship quality between shrimp farmers and processing enterprises in the Mekong Delta. The data were collected through direct interviews with 150 shrimp farmers in Ca Mau, Bac Lieu and Soc Trang Province. The PLS - SEM method was used and the results show that three factors positively affect the quality of the relationship between shrimp farmers and processing enterprises are perceived price, payment conditions and profit-loss sharing. In particular, the perceived price is the most important factor affecting the quality of the relationship between shrimp farmers and processing enterprises. Besides, the study also claims that the relationship quality factor positively impacts the loyalty among shrimp farmers and processing enterprises.