A study was carried out to determine the optimum levels of dietary lysine (Lys) and apparent metabolizable energy (AME) and their interaction with respect to growth performance and carcass traits of growing local Muscovy ducks. For the period from 5-8 weeks of age, a total of 180 local Muscovy ducks was arranged in a factorial design with two factors, dietary Lys level (0.8, 1.0 and 1.2%) and AME levels (12.6 and 13.0 MJ/kg). The crude protein (CP) content of the diets was 19.0%. There were three replicates of 10 birds, balanced for sex per experimental unit. For the period of 9-12 weeks of age, 180 local Muscovy ducks were allocated to a similar design as for the first period, except that the Lys levels were 0.7, 0.9 and 1.1% and the AME levels were 13.4 and 13.8 MJ/kg. The CP content of the diets was 17.0%. The results showed that in the period from 5 to 8 weeks of age, feed and CP intakes, daily weight gain (DWG) and final live weight of the ducks were significantly higher (PKey words: growth, meat quality, nutrition, water fowls, weight gain