The area of entrepreneurship research has attracted the attention of numerous researchers as a way of encouraging growth in multiple countries. The determinants of entrepreneurial behavior have been a subject of interest for several researchers. This study examines the impact of entrepreneurship education and personal characteristics on the graduates who following a master program at the School of Economics, Can Tho University. The result indicates that entrepreneurship education, self-efficacy, entrepreneurial family background, motivation and perceived social support all significantly positively influence entrepreneurial intention. Furthermore, the research also observed the mediating role of perceived social support on the relationship between entrepreneurial family background and entrepreneurial intention. Based on the above results, several managerial implications are proposed to increase entrepreneurial intention of graduates.