The objective of this study is to determine the antioxidant properties of extracts from two non colored (Nang thom and IR50404) and  two colored (Huyet rong and Nep than) rice varieties and to examine the in vivo hepatoprotective potential of bran rice extracts in carbon tetrachloride–treated mice. Different brans of rice varieties were extracted with 55% ethanol and 6,5% acetic solvents. The extracts were analyzed by using Folin-Ciocalteu method for total phenolic (TPC) and the pH-differential method for total anthocyanin content (TAC). The 1,1–diphenyl–2–picrylhydrazyl (DPPH) free radical-scavenging assay was used for antioxidant activity determination. To investigate hepatoprotective effects in vivo, mice orally administered by 2mL/kg/d carbon tetrachloride were given rice bran extract (5g/kg/d) and control silymarin 8 mg/kg/d) for 7 days. Liver health was ascertained by measuring levels of hepatic transaminases (ALT), determining reduced glutathione (GSH), and C vitamin of liver tissue. The results indicated that colored rice bran extracts had better antioxidant properties than non colored rice bran extracts.  Red rice bran (HR) had the highest DPPH scavenging radical activity (90,5%) with the lowest IC50 value (93,9 μg.mL^-1). In in vivo assay, carbon tetrachloride caused a significant increase in alanine aminotransaminase (ALT) in plasma, and a decrease in glutathione and vitamin C in liver of mice, these parameters were reverted towards normalcy after 7 days of treatment by red rice bran extracts with a dose of 5g/kg body weight and silymarin 8 mg/kg p.o  as positive control.