Mekong Delta Region of Vietnam is forecasted to have one of world’s most severe impacts from climate change. There is a significant knowledge gap in research on climate change impacts on tourism in this area. While climate change’s impacts on agriculture and fisheries have received much attention from authorities and researchers, impacts on tourism have largely been ignored. This article reviews the evidence for climate change in the Mekong Delta and its connection to the tourism sector. Firstly, the study lays out quantitative data for climate change in the Mekong Delta. Secondly, the detailed characteristics of the tourism sector in the Mekong Delta are introduced, including tourism resources, tourism incomes, flow of tourists and tourism facilities. The significant connection between these two components is established as a setting context for further study of climate change-tourism relation in the region.