So far, OA (Osteoarthritis) cannot treat and bring articular cartilage back to the normal. The ideal treatment is to stop or slow down the degradation process, decrease pain and improving the quality of life. OA should be first to be considered when animals affected with joint disease and musculoskeletal disorder. Diagnosis as soon as possible will decrease degradation (early diagnosis will decrease degradation); and the progress of OA cannot be controlled with only one treatment plan. Multimodal management need to be done.